Meet the Scientists: Dr. Laurent Debarbieux

The phage whisperer…

While in Paris, Ailsa, Briony and I travelled out to the Institut Pasteur to meet with Dr. Laurent Debarbieux – an expert on Bacteriophages – that is, viruses that infect bacteria. Laurent works at the forefront of research into using bacteriophages to attack and destroy particularly difficult bacterial infections, such as cystic fibrosis infections in the lungs. And while the results have been promising, there is still much work to be done to determine whether bacteriophages can be used reliably to treat clinical infections. At the same time, scientists like Laurent also need to convince our medical and public health authorities to consider the possibilities of using viruses as allies against particularly nasty bacteria! But with the current crisis in antibiotics, the stakes couldn’t be higher!

We had an amazing session discussing bacteriophages with Laurent, hearing his perspectives about how bacteriophages can adapt to infect new host bacteria. In particular, we picked his brains about the scientific creation of our story’s viral hero...

Meet the Scientists: Dr. Jeremy Barr

The main stimulus for The Invisible War came from an article by Jeremy Barr “Bacteriophage adhering to mucus provide a non–host-derived immunity”, published in the prestigious US journal PNAS in June 2013.

Here, Jeremy, along with group leader Forest Rohwer, writer Merry Youle and other co-authors described a mutual symbiosis between mucus-producing (animal) “host” with their phage partners – where the virus partner limits mucosal bacteria, while the animal host presents new bacterial hosts in the mucus for the phage to reproduce.

The enemy of my enemy is a phage

Widely hailed as the discovery of a new immune system, we knew we had to speak to Jeremy Barr about the potential to describe this newly symbiotic relationship as a story in our series. We were overwhelmed by Jeremy’s enthusiasm about collaborating to communicate this discovery as widely as possible.

Jeremy also had an implicit understanding about the power of using narrative to engage people in a topic, something at the heart of our mission. One of our extra incentives for creating this particular story was the challenge of writing a story with a virus as a hero…something we hadn’t anticipated at the start of our process of creating Small Friends stories!